Celva Bio / Treatments / Joint pain & surgery avoidance
§ 001 / Treatment · Joint & orthopedic

The knee, hip, shoulder, and spine
deserve repair. Not replacement.

For patients facing joint-replacement surgery, or told "there's nothing more to do," MSC therapy is a precision-delivered, image-guided alternative. It works with the body's own repair machinery, not around it.

Conditions
18+
Joint indications we screen for
Delivery
2routes
Image-guided intra-articular or systemic IV
Session
1day
Same-day return (hip & spine overnight)
Anatomical study of the knee joint
FIG. 01 · Region Atlas Knee · hip · shoulder · spine
§ 002 / Indications

Four regions.
Eighteen screened conditions.

Not every joint complaint is a candidate for cell therapy. We group by anatomical region and screen each indication against the evidence, your imaging, and your goals.

Region · Knee

The knee

Our most-screened region. Image-guided intra-articular injection delivers MSCs directly to the joint space.

  • Osteoarthritis (I–III)
  • Meniscal tears
  • Patellofemoral pain
  • Post-surgical stiffness
  • ACL & MCL injuries
Learn more
Region · Hip

The hip

Fluoroscopic guidance places cells precisely at the femoral head–acetabular interface.

  • Hip osteoarthritis
  • Labral tears
  • Avascular necrosis (early)
  • Hip impingement / FAI
  • Bursitis (recalcitrant)
Learn more
Region · Shoulder

The shoulder

Ultrasound-guided delivery to glenohumeral joint, rotator cuff tendon, or AC joint as indicated.

  • Rotator cuff tears (partial)
  • Adhesive capsulitis
  • AC joint arthritis
  • Biceps tendinopathy
  • Labral pathology
Learn more
Region · Spine

The spine

Image-guided facet or epidural delivery. Disc therapy is case-by-case, with strict imaging screening.

  • Facet joint arthritis
  • Degenerative disc (screened)
  • SI joint dysfunction
  • Chronic low back pain
  • Post-laminectomy pain
Learn more
§ 003 / Candidacy

Who's a fit,
and who isn't.

We turn down a significant share of inquiries. Not because we can't help. Because MSC therapy isn't the right tool for every problem. Here is the honest screen.

Likely candidate

You are a strong fit if…

  • You have imaging (MRI or weight-bearing X-ray) from within the last 12 months.
  • Your pain is localized to a specific joint or spinal level.
  • You've tried conservative care (PT, NSAIDs, corticosteroid or hyaluronic injection) and improvement plateaued.
  • You're facing a surgical recommendation (joint replacement, arthroscopy, discectomy) and want to delay or avoid it.
  • Your BMI, medications, and systemic health allow an image-guided procedure.
Not a candidate

We would not recommend if…

  • Your imaging shows bone-on-bone, end-stage (Kellgren–Lawrence IV) arthritis with bone loss.
  • There is active joint infection, uncontrolled systemic autoimmune disease, or recent malignancy.
  • Your pain pattern is radicular/neurological rather than joint-based.
  • You're seeking a cure for a mechanical problem that requires hardware (unstable ligament, fracture, severe deformity).
  • You're pregnant, immunocompromised, or on anticoagulants we can't safely pause.
§ 004 / Protocol

The joint protocol,
in specifics.

The general Celva methodology has five stages. For joint indications, here are the numbers that differ: dosing, route, session count, and what pre- and post-care look like.

Source
Allogeneic umbilical-cord MSCs, P3 expansion
Dose range
25–50 million cells per joint
Delivery
Image-guided intra-articular (fluoroscopy + US)
Adjunct
Systemic IV dose, same session
Sessions
One primary; booster at 6 mo if indicated
Anesthesia
Local; no general anesthesia required
Duration on site
~4 hours hospital-side
Return to activity
Walking same day; load-bearing sport at 8–12 weeks
01 / Pre

Imaging review & labs

MRI and weight-bearing X-ray read by our attending. CBC, CMP, inflammatory markers, and coagulation panel within 14 days of procedure.

~2 wks pre-op · virtual
02 / Day-of

Image-guided delivery

Target joint is prepped under sterile technique. Cells are drawn into a 5cc syringe and injected under live fluoroscopic or ultrasound guidance. Position confirmed before release.

~45 min procedure · local anesthesia
03 / Adjunct

Systemic IV infusion

A second allogeneic MSC dose is delivered IV in the infusion suite: 45 minutes, monitored. Joint delivery addresses the target. IV addresses systemic inflammation.

~1 hr · hospital infusion suite
04 / Post

Recovery & return

Short observation. Discharge instructions. Concierge transport back to San Diego. You are walking the same day.

~90 min observation · same-day discharge
05 / Follow-up

Structured check-ins

Scheduled virtual visits at 30, 60, and 90 days. Pain-function scales (KOOS / HOOS / SPADI) and imaging re-read at 6 months.

30 / 60 / 90 days · virtual
§ 005 / Outcomes

What patients
actually report.

Aggregated from the Celva joint registry. Pain reduction is measured on the standardized VAS and KOOS/HOOS/SPADI scales at 6 months. Individual results vary; we measure and report both.

of joint patients
report clinically meaningful pain reduction at 6 months (≥ 30% VAS decrease)
Pending registry update · Knee + hip + shoulder · 2022–2025
facing surgery
postponed or cancelled the recommended orthopedic procedure within 12 months
Pending registry update · Pre-op patients · 2023–2025
average KOOS function score delta, baseline vs. 90 days post-treatment
Pending registry update · Knee-only · 2023–2025
0severe
Grade 3+ adverse events. Transient post-injection soreness is common and resolves < 72 hrs.
Pending registry update · Total joint cohort · 2022–2025

***NoteOutcome figures are placeholder values for design purposes. Final site will display registry-verified numbers updated quarterly.

§ 006 / Registry

Representative
joint cases.

De-identified, consent-verified cases from the Celva registry. Chosen to represent typical trajectories, not only the best outcomes.

Runner, knee in focus
Knee · OA
Case PT-2401 · Knee OA III · 58 M

Replaced a recommended TKA with MSC therapy.

Patient was scheduled for a total knee arthroplasty after two years of conservative care and a corticosteroid course. Bilateral MRI showed Grade III chondral loss, medial compartment. Treated with image-guided intra-articular MSC plus systemic IV. Six-month re-image showed no further progression and KOOS function up from 42 to 76.

Baseline VAS
8 / 10
90-day VAS
3 / 10
180-day VAS
2 / 10
Athlete preparing
Shoulder · RC
Case PT-2387 · Rotator cuff · 46 F

Rotator cuff partial tear, back to swimming.

Masters-level swimmer with a supraspinatus partial tear and refractory tendinopathy after PT and one PRP course. Ultrasound-guided MSC injection to tendon and bursa, plus systemic IV. Returned to full-yardage training at week 10 with no recurrence through one-year follow-up.

SPADI baseline
62
SPADI 90d
24
Return to sport
10 weeks
§ 007 / Investment

Transparent pricing.
Ranges you can plan around.

Joint protocol · single region
$10K–$25K

All-in. Concierge transport + procedure + IV adjunct + follow-up.

Range reflects joint (knee vs. hip vs. spine), delivery complexity (single-region vs. bilateral), and whether an add-on IV dose is indicated. Bilateral and multi-region protocols are priced at the consult, not per-visit.

We do not take insurance. Cell therapy is not yet covered in the United States. We publish clear numbers so you can decide before you book a consult.

See full pricing matrix →
§ 009 / Questions

Joint-specific
questions.

Q.01 If I'm scheduled for a knee replacement, is it too late?
Probably not, but imaging tells us. Most "too late" candidates we turn down show end-stage Kellgren–Lawrence IV with bone-on-bone and subchondral bone loss. Grade II and III are often strong candidates, even if surgery has been recommended. Send us your most recent MRI and we'll read it before your consult.
Q.02 Is it image-guided? Can it miss the target?
Every intra-articular delivery is performed under live fluoroscopy or ultrasound by an attending physician. Needle position is confirmed before cells are released. "Blind" injection (common at non-hospital clinics) is never used for joint work at Celva.
Q.03 Will it regrow cartilage?
We won't tell you that. MSCs are paracrine signalers. They release factors that modulate inflammation and support the body's own repair machinery. In joints, the typical observation is reduced pain, improved function, and slowed progression. Some patients show cartilage preservation on follow-up imaging. True regrowth is rare, and we don't lead with it.
Q.04 How is this different from PRP or a cortisone shot?
PRP concentrates your own platelets and growth factors. Cortisone is an anti-inflammatory steroid. MSC therapy introduces living, screened, expanded mesenchymal stem cells that signal for a longer therapeutic window. Three different tools. Many patients arrive having tried PRP and cortisone first, which is usually the right order.
Q.05 What does recovery look like for a joint case?
You walk the same day. Expect mild soreness at the injection site for 24–72 hours. No heavy impact or gym work for 7 days. Progressive return to full load at 6–8 weeks. Sport-specific return at 8–12 weeks depending on joint and baseline. You'll have a written protocol before you fly home.
§ 010 · Start here

See if you're
a candidate.

Send us your imaging, tell us about your joint, and we'll tell you plainly whether MSC therapy is the right next step. If it isn't, we'll say so.

Book a consult →
Not medical advice. Individual results vary. All patients undergo screening before treatment is recommended. Autologous and allogeneic cell therapies at Celva Bio are regulated by COFEPRIS in Mexico.