Celva Bio/ Joint pain/ Spine, neck & back
§ 001 · Spine · MSC therapy

Before you consent
to a fusion.

For discogenic pain, facet arthropathy, and early degenerative disc disease, MSC therapy is worth reviewing before a fusion or disc replacement. Spine cases need more evaluation, not less, and we do it carefully.

Scope
Disc & facet

Discogenic pain, facet arthropathy, and early DDD in lumbar and cervical spine.

Response window
8–16 wks

Spine response is typically the slowest of the joint regions. Peak at six months.

Investment
$10K–$25K

Spine cases require fluoroscopic delivery at multiple levels. Exact figure confirmed after evaluation.

§ 002 · Candidacy

Spine cases get
harder scrutiny.

Not every back or neck pain is a spine-structure problem, and not every spine-structure problem responds to biologics. The point of the evaluation is to separate those three categories before anyone commits.

Patients who do well have identifiable disc or facet pathology, confirmed imaging findings, and pain mechanisms that match. They've often been through PT, injections, and ablations without durable relief.

We decline spine cases more than any other region. Neurologic compromise, severe instability, and tumor or infection findings require different care pathways. We'll route you accordingly.

Strong fit

Discogenic pain, early DDD

MRI-confirmed disc pathology, positive provocative discography or modic changes, pain pattern consistent with findings.

Also a fit

Facet arthropathy, chronic axial pain

Facet-mediated pain confirmed by diagnostic block response. Non-radicular pain pattern.

Not a fit

Neuro compromise, severe instability

Progressive neurologic findings, spondylolisthesis requiring stabilization, severe stenosis, tumor, or infection. Surgery or different care, we refer.

§ 003 · Indications

Spine conditions
we evaluate.

Disc

Discogenic pain & DDD

Early disc degeneration with matching pain pattern and preserved disc height.

  • Single or two-level
  • Modic I or II changes
  • Preserved height
Facet

Facet arthropathy

Facet-mediated axial pain confirmed by diagnostic block response.

  • Positive block response
  • Non-radicular pattern
  • Chronic > 6 months
Chronic

Post-surgical & refractory

Persistent pain after decompression, failed back syndrome, post-ablation patients still searching.

  • Post-laminectomy drift
  • Failed back syndrome
  • Refractory axial pain
§ 004 · Protocol

Fluoroscopic
multi-level delivery.

Spine injections require fluoroscopic guidance with contrast confirmation at every level. No ultrasound shortcuts. No blind injection.

Intradiscal delivery for disc cases, intra-facet for facet pathology, or combined for mixed presentations. Dose calibrated per level and your imaging.

Performed at Hospital Angeles, Tijuana, under light sedation. Most patients travel home the following morning with activity modifications in place.

01 / Screen

MRI + mechanism map

Imaging cross-checked against pain pattern and prior diagnostic blocks. Level selection is deliberate.

02 / Plan

Target levels

Intradiscal, intra-facet, or combined. One to three levels typical.

03 / Deliver

Fluoroscopic injection

Contrast confirmation at every level before cell release. Sterile cGMP handling throughout.

~60–90 min · sedation
04 / Adjunct

Systemic IV

Supporting dose for systemic anti-inflammatory effect.

05 / Follow-up

30 / 60 / 90 days

ODI and VAS tracked at each interval. Imaging re-read at six months.

§ 005 · Timeline

Spine is the
slowest joint region.

~ 4–6 wks
Activity resumption

Post-procedure soreness resolves. Structured return to walking and gentle loading.

~ 90 days
Measurable shift

ODI scores begin improving for responders. Morning stiffness and sit-to-stand patterns shift.

~ 180 days
Peak window

Best achievable relief. Some patients benefit from a second session at six months.

12+ months
Durability window

Responders typically hold gains for one to three years with ongoing core conditioning.

Spine is the joint region most likely to require a second session. If your six-month response is partial, we evaluate candidacy for a booster rather than assuming.

The honest limit

Spine fusion recommendations often turn out to be the correct call. We aren't in the business of talking patients out of surgery they need. The evaluation exists to sort which category your case is in.

§ 006 · Questions

Spine-specific
questions.

Q.01Can MSC therapy avoid spinal fusion?
For patients with discogenic or facet-mediated pain without instability or neurologic compromise, it is a legitimate path to evaluate. For instability patterns and progressive neuro findings, fusion is typically the right answer.
Q.02What if I have a herniated disc?
Depends on the type and whether there's neurologic compromise. Large extruded herniations with progressive weakness or cauda equina signs are surgical cases. Contained herniations with chronic axial pain are evaluated individually.
Q.03Will this help sciatica?
Sciatica is a symptom, not a structural diagnosis. The structural driver determines whether MSC therapy is appropriate. Compressive structural pathology may need decompression rather than biologics.
Q.04Can I drive home the same day?
No. Spine patients stay overnight. Concierge transport handles pickup and return. Standard recovery includes modified activity for the first week.
§ 008 · Start here

Start with a
careful read.

A spine consult is a physician reviewing your imaging, history, and pain pattern, and telling you plainly whether MSC therapy is a realistic option or whether surgery is the honest answer.

Book a consult →
Not medical advice. Individual results vary. Spine candidacy undergoes additional screening including neurologic assessment.