PT-1037 · 2026.03
Knee · bilateral OA · stage 3
The orthopedist gave me two options. Celva gave me a third one I could live with.
§ 001 / Introduction
Repair, before
replacement.
Celva Bio is a physician-led clinic inside Hospital Angeles, Tijuana. We deliver mesenchymal stem cell therapy (the body's own repair-coordinating cells) for joint pain, longevity, and the conditions standard care hasn't solved.
Experience
20+ yrs
Regenerative medicine & tissue engineering
Laboratory
cGMP
cGMP-compliant cell expansion
Turnaround
1 day
San Diego → treatment → home
Fig. 01 · Clinical setting
Hospital Angeles, Tijuana. cGMP-compliant regenerative medicine suite.
→ Physician team licensed in Mexico
→ cGMP-compliant cell processing
→ Allogeneic umbilical-cord MSCs · passage 3
→ Physician team reviews every case
→ Inquiries declined when not a fit
→ 20-min concierge transfer from San Diego
→ Physician team licensed in Mexico
→ cGMP-compliant cell processing
→ Allogeneic umbilical-cord MSCs · passage 3
→ Physician team reviews every case
→ Inquiries declined when not a fit
→ 20-min concierge transfer from San Diego
§ 002 / Treatment tracks
Three doors.
Three doors.
One standard of care.
Most patients arrive through one of three tracks. Each is physician-reviewed against the same criteria: indication, imaging, prior treatments tried, and candidacy risk.
Track
Presenting condition
Delivery
Investment
Evaluation
Track 01
Joint & spine
Chronic knee, hip, shoulder, or spine pain. Surgery recommended or being considered. You want a legitimate alternative.
"I want my body back. Without cutting for it."
Image-guidedTargeted injection
$10K–$25K1–2 sessions
Standard
→
Track 02
IV longevity
Proactive, performance-oriented, already dialed in on your health. IV MSC protocols for patients who don't wait for a crisis.
"My body is the asset. I want to stay ahead of it."
IntravenousSystemic infusion
$15K–$40K+Single or staged
Standard
→
Track 03
Neurologic & complex
PT, injections, a surgery that didn't hold. Autoimmune, post-viral, or neurologic conditions that deserve a deeper evaluation.
"I don't want false hope. I want an honest conversation."
IV ± targetedProtocol-specific
Individually pricedAfter extended eval
Extended
→
Extended evaluation = additional intake by the physician team in Mexico (records review, imaging read, multidisciplinary consult) before a candidacy decision. Extended-tier inquiries are declined when not a fit.
§ 003 / Experience
San Diego to treatment and back. In one day.
Celva operates inside Hospital Angeles, Tijuana, Mexico's most recognized hospital name for 40 years. Twenty minutes from the U.S. border.
Our team handles the day: private transport, border logistics, clinical coordination, aftercare. You handle the recovery.
§ 004 / Methodology
Five steps.
Five steps.
Physician-led throughout.
Every Celva patient moves through the same five-step process. Intake first. The physician team in Mexico assesses candidacy before any treatment is recommended, and a significant share of inquiries are declined.
You fly into San Diego. We take care of the day.
01
~45 min · virtual
Intake & physician review
Your first call is with a Celva patient coordinator who gathers your medical history, imaging, prior treatments, and goals. The physician team at Hospital Angeles, Tijuana then reviews your case independently and returns a recommendation.
Celva coordinator → physician team
02
~45 min · SD → hospital
Private transport
Concierge pickup from your San Diego hotel. Medical fast-pass crossing. You are accompanied. Never sent alone.
Celva concierge team
03
~30 min · in-person
Clinical intake
Vitals, informed consent, and a walk-through of the day. Questions welcomed. Intake is not a formality.
Attending physician + nursing
04
~45 min · procedure
Treatment
MSC infusion (IV) or image-guided targeted injection. Hospital procedure suite, physician supervision throughout.
Attending + lab lead
05
30 · 60 · 90 day
Return & follow-up
Concierge transport back to San Diego once the physician team has authorized discharge — most patients are home the same day. Scheduled virtual follow-ups at 30, 60, and 90 days.
Clinical team + portal
§ 005 / Mechanism
How the cells work.
How the cells work.
Four simultaneous mechanisms.
Mesenchymal stem cells initiate a signaling cascade that operates at four levels at once. Together these mechanisms address the upstream biology behind chronic conditions — changing the environment so the body's own repair capacity can function again. The signaling persists well beyond the cells themselves.
Allogeneic umbilical-cord MSCs. Screened donors. cGMP-compliant cell processing. Physician supervision at a full hospital. Not a wellness clinic.
How the cells work — four simultaneous mechanisms
Anti-inflammatory
Suppresses the chronic inflammatory signaling driving pain, dysfunction, and progressive tissue damage — systemically.
Anti-fibrotic
Interrupts the fibrotic cascade that replaces functional tissue with scar, a downstream consequence of chronic inflammation.
Immunomodulatory
Recalibrates dysregulated immune activity across the body without systemic immune suppression.
Pro-angiogenic
Supports formation of new vascular networks, improving tissue perfusion and creating a more favorable systemic repair environment.
- Source
- Allogeneic umbilical-cord
- Screening
- 16-panel donor
- Expansion
- cGMP-compliant · P3
- Cryo
- Proprietary media
- Delivery
- IV or image-guided
- Supervision
- Attending physician
Fig. 02 · Paracrine signalling cascade
§ 006 / Clinical follow-up
Patients,
Patients,
not case studies.
Representative cases from our clinical follow-up records. De-identified. Verified with patient consent. Timeline is the patient's own.
PT-1052 · 2025.11
IV · systemic recovery
I stopped waiting for something to go wrong before doing anything about it.
PT-1063 · 2026.01
Shoulder · rotator cuff partial
The surgeon said shave-and-hope. I wanted a different conversation.
§ 007 / Frequently asked
The questions everyone asks first.
Most patients research for weeks before reaching out. These are the questions we hear on almost every first call. Straight answers. Not reassurances.
Q.01 Why isn't this FDA-approved in the United States? +
MSC therapies are still working through U.S. clinical trials. That process takes years, even for treatments with strong evidence. Hospital Angeles is regulated by COFEPRIS, Mexico's federal regulatory body, where licensed physicians administer cell-based therapies in a fully supervised clinical setting. Patients access the treatment now, under physician oversight, rather than waiting another decade for U.S. approval.
Q.02 Is it safe to travel to Tijuana for treatment? +
Celva Bio operates inside Hospital Angeles. A full hospital, not a standalone clinic or wellness center. Private concierge transport from San Diego, medical fast-pass border crossing, and a team member with you throughout. We don't send patients alone.
Q.03 Where do the cells come from? +
From screened umbilical-cord tissue donated after full-term healthy births. Cells are expanded in a cGMP-compliant laboratory operated by the physician team in Mexico and preserved using proprietary cryopreservation. No embryonic cells are used. The cells are allogeneic. You don't need a harvest procedure yourself.
Q.04 What does treatment actually cost? +
It depends on your protocol. Most orthopedic and surgery-avoidance patients invest between $10,000 and $25,000. IV longevity programs range from $15,000 to $40,000+. Neurologic and complex-condition programs are priced individually. Insurance does not cover these treatments.
Q.05 How do I know if I'm a good candidate? +
Honest answer: not everyone is. Our coordinator collects your medical history, current condition, imaging, and goals, and passes it to the physician team in Mexico for independent review. A significant share of inquiries are declined. If you're not a fit, we'll say so plainly.
§ 008 / Book
Start with a conversation.
No pressure. No commitments. Your first call is with a Celva patient coordinator who collects your information and passes it to the physician team in Mexico for independent review. Bring every question you have — about your condition, the treatment, the process, and whether Celva is the right fit.
These therapies are not FDA-approved. Treatments are performed in Mexico by licensed physicians in a hospital setting. Individual results may vary. Not medical advice.