Celva Bio / Treatments / IV longevity & performance
§ 002 / Treatment · Systemic & preventive

Maintain the body,
before it asks for repair.

Systemic MSC infusion is the quieter side of regenerative medicine. Delivered intravenously, it works everywhere at once. For patients moving from reactive care to proactive maintenance: recovery, inflammation, performance, resilience.

Session
45min
In-chair infusion time
Dose
100–300M
Allogeneic MSCs, per infusion
Cadence
2–4/yr
Typical maintenance schedule
IV infusion setup in clinical light
FIG. 02 · Systemic Delivery Whole-body distribution
§ 002.1 / Audience

Three patients.
Same therapy, different goals.

Systemic MSC therapy isn't one protocol. We tailor dose, cadence, and adjuncts to the reason you walk in.

I.
Track · Longevity

The proactive adult

You're 45–70, feel "fine," and want to stay ahead of decline. Inflammation markers are creeping. Sleep is slipping. Recovery takes longer than it used to. MSC maintenance is the systemic upstream move.

  • CRP, HOMA-IR, ApoB as baselines
  • 2 infusions / year, booked around travel
  • Paired with sleep + strength protocol
II.
Track · Recovery

The athlete or operator

Training volume is high and the body is signaling. Soft-tissue niggles, chronic low-grade tendinopathy, slower return-to-train. You need faster clearance of inflammatory load without steroids that blunt adaptation.

  • Dose timed to block periodization
  • 3–4 infusions / year at volume peaks
  • Readiness monitoring: HRV + sleep + force plate
III.
Track · Post-event

After surgery, illness, or injury

You're recovering from a major surgery, a serious illness, or a systemic event (long COVID, chemo, cardiac procedure). You want the fastest honest path back to baseline function, cleared through your primary physician.

  • Requires medical clearance + records
  • 1–3 infusions, scheduled close together
  • Handoff to your care team after
§ 002.2 / Mechanism

Where the cells
actually go.

IV-delivered MSCs are not "pumped into a joint." They circulate. Most transit the lungs first (which is where they do some of their most interesting work) and from there signal throughout the body.

01

Infusion

Screened allogeneic MSCs suspended in a small volume of saline, delivered through a peripheral IV over ~45 minutes.

02

First-pass lungs

Most cells transit the pulmonary capillary bed first. Residence time here is hours, and where a large share of immunomodulatory signaling occurs.

03

Systemic distribution

Cells traffic to sites of inflammation, ischemia, and tissue stress, attracted by cytokine gradients released by damaged tissue.

04

Paracrine signaling

Cells release extracellular vesicles and growth factors that modulate local immune response, reduce inflammation, and support resident repair cells.

05

Clearance

MSCs are cleared within ~14 days. The therapeutic window extends longer, driven by downstream effects on the body's own repair machinery.

NOTE This is a simplified model. MSC behavior in vivo remains an active research area, and clinical benefit is not fully explained by any single mechanism. We describe what we observe and what the literature supports.

§ 002.3 / Protocol

The IV protocol,
in specifics.

Same methodology as our joint program, different numbers. No anesthesia, no procedure room, no recovery time. You arrive, infuse, leave.

Source
Allogeneic umbilical-cord MSCs, P3 expansion
Dose range
100–300M cells per infusion
Delivery
Peripheral IV, saline carrier
Adjunct
NAD+, glutathione, or peptide stack on request
Sessions
1–4 per year depending on goal
Anesthesia
None
Duration on site
~2 hours total
Return to activity
Same day, full normal activity
01 / Pre

Baseline panel

Comprehensive blood work: CBC, CMP, inflammatory markers (CRP, IL-6), ApoB, HOMA-IR, HbA1c. Sleep, HRV, and symptom questionnaire. Baseline we can measure against.

~2 wks pre-visit · virtual
02 / Day-of

Intake & vitals

Arrival, updated vitals, IV placement by our infusion RN. Private infusion suite. You'll be awake, comfortable, and can work or read.

~20 min intake
03 / Infusion

MSC delivery

Cells drawn from cryopreservation, warmed and suspended in saline, infused at a controlled rate over ~45 minutes. Vitals monitored throughout. Sensations are typically nothing beyond mild warmth.

~45 min · infusion suite
04 / Observation

Post-infusion hold

Short observation, hydration, discharge instructions. Most patients leave within 30 minutes of the infusion ending.

~30 min · hospital suite
05 / Follow-up

Re-measure, re-plan

Same biomarker panel repeated at 60 and 90 days. We compare deltas against baseline and co-author the next-cycle plan. If there's no measurable response, we don't schedule another infusion.

60 / 90 days · virtual
§ 002.4 / Experience

What patients
actually feel.

A realistic timeline, infusion day through 6 months, of what IV recipients typically report. Not everyone follows this curve, and we tell you when yours is outside it.

Day 0
In-chair

Mild warmth as the infusion runs. Occasional brief flush. Nothing dramatic. This is a quiet procedure by design.

Day 1–3
Immune echo

Some patients describe a brief "activation": mild fatigue, slightly elevated temperature, vivid sleep. Typically subsides by day 3.

Week 2–4
Early signal

Sleep quality and recovery first. Small things: legs heavier for less time after training, calmer inflammation, fewer minor aches.

Month 2–3
Measurable shift

Inflammatory markers trend down on re-draw. HRV often up. Subjective energy and cognitive clarity reports peak here for most patients.

Month 6
Decision point

Re-measurement panel. We decide together: maintain, extend cadence, or conclude this cycle. No automatic re-bookings.

§ 002.5 / Outcomes

What the registry
actually shows.

Aggregated from the current IV cohort. These are biomarker and symptom deltas, not "feel" reports. Individual results vary; we measure and publish both.

median CRP
reduction in high-sensitivity CRP at 90 days post-infusion
Pending registry update · Longevity + athlete tracks
HRV median
heart-rate variability improvement at 60 days vs. baseline
Pending registry update · Patients with baseline < 45 ms
subjective
report meaningful improvement in recovery, sleep, or energy at 90 days
Pending registry update · All IV tracks · Self-report
0severe
Grade 3+ adverse events. Transient flushing / fatigue < 72 hrs in ~8% *** of patients.
Pending registry update · Total IV cohort · 2022–2025

***Note Outcome figures are placeholder values for design purposes. Final site will display registry-verified numbers updated quarterly.

§ 002.6 / Investment

Transparent pricing.
Per protocol.

Investment · IV longevity

Per protocol

Includes consult, full biomarker panels, MSC infusion, concierge transport from San Diego, and structured follow-up. Most patients return two to four times per year. Exact figure confirmed after the physician evaluation.

$15K–$40K+

Pricing includes concierge transport from San Diego, full biomarker panels, and follow-up. We do not take insurance. Adjunct stacks (NAD+, glutathione, peptides) priced separately.

See full pricing matrix →
§ 002.8 / Questions

IV-specific
questions.

Q.01 Isn't this just an expensive IV vitamin drip?
No. IV vitamin drips deliver water-soluble nutrients: electrolytes, B vitamins, glutathione, and so on. They have a place, but they're not cell therapy. A Celva IV is an infusion of living, screened, P3-expanded allogeneic mesenchymal stem cells. The biological mechanism and price are both in a different category.
Q.02 How long does the effect last?
MSCs themselves clear in ~14 days. Their downstream effects (on immune balance, local repair, biomarker trajectory) commonly persist 3–6 months for most patients, which is why our maintenance cadence is 2–4 per year. Some patients feel shifts longer. Some need tighter cadence. We re-measure before we re-book.
Q.03 Do I need imaging or specific diagnoses to qualify?
No. IV tracks are open to generally-healthy adults who complete our medical intake and baseline bloodwork. If you have a specific diagnosis (autoimmune, cardiac, post-surgical), we require clearance from your treating physician and we'll often want additional testing before dosing.
Q.04 Can I combine this with my peptide / hormone / NAD protocol?
Usually yes, and we often co-administer NAD+ or glutathione in the same session. Peptides and hormone therapy we want a full picture of before dosing. Some combinations accelerate results, some blunt the signal, and a few we'd recommend spacing out. Bring your list to the consult.
Q.05 What's the downside I should know about?
Three honest ones. First: effects are systemic and quiet. Some patients don't feel much subjectively even when biomarkers shift, which can feel underwhelming if you were expecting a peak. Second: this is not FDA-approved in the US. We operate under COFEPRIS regulation in Mexico, and that's a decision you should make eyes-open. Third: cost. You're paying cash for a therapy with strong early evidence and unsettled long-term data. We tell you this before we book you.
§ 002.9 · Start here

Start with one
honest infusion.

Begin with a single discovery visit. Full baseline panel, one infusion, a protocol we build together. If it's not delivering measurable signal at 90 days, we say so. And we don't book the next one.

Book a consult →
Not medical advice. Individual results vary. All patients undergo screening before treatment is recommended. Autologous and allogeneic cell therapies at Celva Bio are regulated by COFEPRIS in Mexico.