PT-1037 · 2026.03
Knee · bilateral OA · stage 3
The orthopedist gave me two options. Celva gave me a third one I could live with.
§ 001 / Introduction
Repair, before
replacement.
Celva Bio is a physician-led clinic inside Hospital Angeles, Tijuana. We deliver mesenchymal stem cell therapy (the body's own repair-coordinating cells) for joint pain, longevity, and the conditions standard care hasn't solved.
Experience
20+ yrs
Regenerative medicine & tissue engineering
Laboratory
ISO-7
cGMP-certified cell expansion
Turnaround
1 day
San Diego → treatment → home
Fig. 01 · Clinical setting
Hospital Angeles, Tijuana. ISO-7 cGMP regenerative medicine suite.
→ COFEPRIS-approved protocol
→ ISO-7 cGMP laboratory
→ Allogeneic umbilical-cord MSCs · passage 3
→ Physician evaluation · never coordinators
→ Inquiries declined when not a fit
→ 20-min concierge transfer from San Diego
→ COFEPRIS-approved protocol
→ ISO-7 cGMP laboratory
→ Allogeneic umbilical-cord MSCs · passage 3
→ Physician evaluation · never coordinators
→ Inquiries declined when not a fit
→ 20-min concierge transfer from San Diego
§ 002 / Treatment tracks
Three doors.
Three doors.
One standard of care.
Most patients arrive through one of three tracks. Each is physician-reviewed against the same criteria: indication, imaging, prior treatments tried, and candidacy risk.
Track
Presenting condition
Delivery
Investment
Evaluation
Track 01
Joint & spine
Chronic knee, hip, shoulder, or spine pain. Surgery recommended or being considered. You want a legitimate alternative.
"I want my body back. Without cutting for it."
Image-guidedTargeted injection
$10K–$25K1–2 sessions
Standard
→
Track 02
IV longevity
Proactive, performance-oriented, already dialed in on your health. IV MSC protocols for patients who don't wait for a crisis.
"My body is the asset. I want to stay ahead of it."
IntravenousSystemic infusion
$15K–$40K+Single or staged
Standard
→
Track 03
Neurologic & complex
PT, injections, a surgery that didn't hold. Autoimmune, post-viral, or neurologic conditions that deserve a deeper evaluation.
"I don't want false hope. I want an honest conversation."
IV ± targetedProtocol-specific
Individually pricedAfter extended eval
Extended
→
Extended evaluation = additional intake (records review, imaging read, multidisciplinary consult) before a candidacy decision. Extended-tier inquiries are declined when not a fit.
§ 003 / Experience
San Diego to treatment and back. In one day.
Celva operates inside Hospital Angeles, Tijuana, Mexico's most recognized hospital name for 40 years. Twenty minutes from the U.S. border.
Our team handles the day: private transport, border logistics, clinical coordination, aftercare. You handle the recovery.
§ 004 / Methodology
Five steps.
Five steps.
Physician-led throughout.
Every Celva patient moves through the same five-step protocol. Consultation first. We assess candidacy before recommending any treatment, and turn down a significant share of inquiries.
You fly into San Diego. We take care of the day.
01
~45 min · virtual
Consult & screening
Review of medical history, imaging, prior treatments, goals. Physician-led, never a coordinator.
w/ Dr. Amescua or Dr. Ambrosio Nuño
02
~45 min · SD → hospital
Private transport
Concierge pickup from your San Diego hotel. Medical fast-pass crossing. You are accompanied. Never sent alone.
Celva concierge team
03
~30 min · in-person
Clinical intake
Vitals, informed consent, and a walk-through of the day. Questions welcomed. Intake is not a formality.
Attending physician + nursing
04
~45 min · procedure
Treatment
MSC infusion (IV) or image-guided targeted injection. Hospital procedure suite, physician supervision throughout.
Attending + lab lead
05
30 · 60 · 90 day
Return & follow-up
Concierge transport back to San Diego the same evening. Scheduled virtual follow-ups at 30, 60, and 90 days.
Clinical team + portal
§ 005 / Mechanism
MSCs don't replace tissue.
MSCs don't replace tissue.
They coordinate repair.
Mesenchymal stem cells don't turn into cartilage. They don't regrow a disc. What they do is signal. They release cytokines and growth factors that modulate inflammation and recruit the body's own repair machinery to tissue stuck in a chronic injury loop.
Put plainly: MSCs are paracrine signalers. Screened umbilical-cord tissue donors. ISO-7 cGMP expansion. Physician supervision at a full hospital. Not a wellness clinic.
- Source
- Allogeneic umbilical-cord
- Screening
- 16-panel donor
- Expansion
- ISO-7 cGMP · P3
- Cryo
- Proprietary media
- Delivery
- IV or image-guided
- Supervision
- Attending physician
Fig. 02 · Paracrine signalling cascade
§ 006 / Registry
Patients,
Patients,
not case studies.
Representative cases from the Celva registry. De-identified. Verified with patient consent. Timeline is the patient's own.
PT-1052 · 2025.11
IV · systemic recovery
I stopped waiting for something to go wrong before doing anything about it.
PT-1063 · 2026.01
Shoulder · rotator cuff partial
The surgeon said shave-and-hope. I wanted a different conversation.
§ 007 / Frequently asked
The questions everyone asks first.
Most patients research for weeks before reaching out. These are the questions we hear on almost every first call. Straight answers. Not reassurances.
Q.01 Why isn't this FDA-approved in the United States? +
MSC therapies are still working through U.S. clinical trials. That process takes years, even for treatments with strong evidence. Hospital Angeles is authorized by COFEPRIS, Mexico's federal regulatory body, to administer cell-based therapies in a fully supervised clinical setting. Patients access the treatment now, under physician oversight, rather than waiting another decade for U.S. approval.
Q.02 Is it safe to travel to Tijuana for treatment? +
Celva Bio operates inside Hospital Angeles. A full hospital, not a standalone clinic or wellness center. Private concierge transport from San Diego, medical fast-pass border crossing, and a team member with you throughout. We don't send patients alone.
Q.03 Where do the cells come from? +
From screened umbilical-cord tissue donated after full-term healthy births. Cells are expanded in our ISO-7 cGMP laboratory and preserved using proprietary cryopreservation. We don't use embryonic cells. The cells are allogeneic. You don't need a harvest procedure yourself.
Q.04 What does treatment actually cost? +
It depends on your protocol. Most orthopedic and surgery-avoidance patients invest between $10,000 and $25,000. IV longevity programs range from $15,000 to $40,000+. Neurologic and complex-condition programs are priced individually. Insurance does not cover these treatments.
Q.05 How do I know if I'm a good candidate? +
Honest answer: not everyone is. We review your medical history, current condition, imaging, and goals before recommending any path. We turn down a significant share of inquiries. If you're not a fit, we'll say so plainly.
§ 008 / Book
Start with a conversation.
No pressure. No commitments. A consult is your chance to ask every question you have: about your condition, the treatment, the process, and whether Celva is the right fit.
Not medical advice. Individual results vary. All patients undergo screening before treatment is recommended. Autologous and allogeneic cell therapies at Celva Bio are regulated by COFEPRIS in Mexico.